So the question is, can we combine them to have a keyboard shortcut like Win+Alt+PrtScn to take the screenshot of the active window and automatically save it to a file? As we all know, we can do Alt+PrtScn to take a screenshot of the active window in almost all Windows versions. Windows 10 has a new way to take a screenshot of the entire desktop and automatically save it in the Screenshots folder under Pictures by simply press the Win + PrtScn keyboard shortcut.